Enrofloxacin Water Soluble Powder 10% 20%
FOR VETERINARY USE
Composition: Per 1 gram contains
Enrofloxacin 200mg
Description:
This product is white or light yellow powder.
Pharmacological Action:
Pharmacodynamics
Enrofloxacin is an animal-specific bactericidal broad-spectrum antibacterial drug.
Escherichia, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Septica Pseudomonas, Staphylococcus aureus, Mycoplasma, Chlamydia, etc. all have good effects, and have weak effects on Pseudomonas aeruginosa and Streptococcus, but weak on anaerobic bacteria. It has obvious antibacterial effect on sensitive bacteria. The antibacterial mechanism of this class of drugs is to act on the DNA gyrase (type II topoisomerase) of bacterial cells, which interferes with the replication, transcription, repair and recombination of bacterial DNA, and the bacteria cannot grow and reproduce normally and die. Its effect is obviously concentration-dependent, and the blood drug is concentrated
The best therapeutic effect can be exerted when the degree is greater than 8 times the MIC.
Pharmacokinetics
Most monogastric animals can be well absorbed by oral administration of this product, and the plasma concentration reaches its peak within 0.5 to 2 hours.
Food in the stomach can delay the rate of drug absorption, but does not affect the amount absorbed. The bioavailability of oral administration in chickens is 62.2% to 84%. This product is widely distributed in animals and can enter tissues and body fluids (including bones and prostate). Except that the concentration of cerebrospinal fluid is only 6% to 10% of serum concentration, the drug concentration in almost all tissues is higher than that in plasma. The accumulation of white blood cells reached 140 times the plasma concentration. Liver metabolism is mainly to remove the ethyl group of the piperazine ring at the 7-position to produce ciprofloxacin, followed by oxidation and glucuronic acid binding. Elimination is mainly excreted through the kidneys (through renal tubular secretion and glomerular filtration), and 15%-50% is excreted in the urine in its original form. Chicken
The serving half-life is 9.1 to 14.2 hours.
Drug Interactions:
It has a synergistic effect when combined with aminoglycosides and broad-spectrum penicillin.
Ca2+, Mg2+, Fe3+, Al3+ and other heavy metal ions can chelate with this product and affect absorption.
Combined use with theophylline and caffeine can inhibit the latter's metabolism, increase the blood concentration of theophylline and caffeine abnormally, and even cause symptoms of theophylline poisoning.
It has the effect of inhibiting liver drug enzymes. Combined with drugs metabolized in the liver, it can reduce its clearance rate and increase blood drug concentration.
Probenecid can inhibit the secretion and excretion of its renal tubules and prolong its half-life.
Role and use
Fluoroquinolone antibacterial drugs. Used for avian bacterial diseases and mycoplasma infections.
Dosage and Administration:
For chicken: Use this product 0.125 to 0.375 g per 1 L of water twice a day for 3 to 5 days.
Adverse Reactions:
(1) It can cause degeneration of cartilage in young animals, causing claudication and pain.
(2) Digestive system reactions include vomiting, abdominal pain, and abdominal distension.
(3) Skin reactions include erythema, itching, urticaria and photosensitivity.
Precautions:
It is forbidden during the laying period of laying hens.
Withdrawal Period: Chicken: 8 days.
Package: 50g, 100g, 150g, 200g, 250g, 500g
Storage: Sealed and Stored in a cool and dry place.
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