Colistin Sulphate 1200000 IU & Amoxycillin Trihydrate 20% WSP Powder for oral administration Composition: Contains per gram powder: Colistin Sulphate........................................1 200 000IU. Amoxycillin trihydrate….....................................….200mg. Carrier ad........…...................................1g. Description: The combination of amoxicillin and colistin acts additive. Amoxicillin is a semisynthetic broad-spectrum penicillin with a bactericidal action against both Gram-positive and Gram-negative bacteria. The range of effect includes Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase-negative Staphylococcus and Streptococcus, spp. The bactericidal action is due to inhibition of cell wall synthesis. Amoxicillin is mainly excreted in urine. A major part can also be excreted in bile. Colistin is an antibiotic from the group of polymyxins with a bactericidal action against Gram-negative bacteria like E. coli, Haemophilus and Salmonella. Since colistin is absorbed for a very small part after oral administration only gastrointestinal indications are relevant. Indications: Gastrointestinal, respiratory and urinary tract infections caused by amoxicillin and colistin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, E. coli, Erysipelothrix, Haemophilus, Pasteurella, Salmonella, penicillinase negative Staphylococcus and Streptococcus spp., in calves, goats, poultry, sheep and swine. Contra-indications: Hypersensitivity to amoxicillin and/or colistin. Administration to animals with a seriously impaired renal function. Concurrent administration of tetracyclines, macrolides and lincosamides. Administration to animals with an active microbial digestion. Side effects: Hypersensitivity reactions, renal dysfunction, neurotoxicity and neuromuscular blockade. Dosage: For oral administration:
Calves, goats and sheep: Twice daily 5 g per 100 kg body weight for 3 - 5 days. Poultry and swine: 1 kg per 1000 - 2000 litres of drinking water for 3 - 5 days.
Note: for pre-ruminant calves, lambs and kids only. Please note: Before adding to the drinking water make a presolution of 1 kg Colistin Sulphate 1200000 IU +Amoxycillin Trihydrate 20% WSP per 20 liters of water with a temperature of 40º C. Withdrawal times - For meat: 8 days. Warning Keep out of reach of children. Packing Sachet of 100 g and jar of 500 and 1000 g.